Effects of NS-398 on vascular endothelial growth factor expression in human tongue squamous cell carcinoma Tca8113 cell line
- VernacularTitle:NS-398对人舌鳞癌细胞系Tca8113表达VEGF的影响
- Author:
Zengjian LI
;
Mingliang YANG
;
Qiang LIU
;
Xiaoju SUN
- Publication Type:Journal Article
- Keywords:
COX-2;
Vascular endothelial growth factor;
NS-398
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of NS-398 on the expression of vascular endothelial growth factor (VEGF) in human tongue squamous cell carcinoma Tca8113 cells.Methods:Tca 8113 cells were exposed to the COX-2 inhibitor NS-398 at 150 ?mol/L for 48,72 and 96 h respectively,then cells were collected. VEGF expression was examined by RT-PCR and Western blot. Results:NS-398 inhibited VEGF mRNA and protein expression time-dependently in Tca8113 cells. Conclusion:NS-398 may inhibit VEGF expression in tongue squamous cell carcinoma.
