The effect of estrogen on the expression of IL-1 in remodeling osteoporotic alveolar bone
- VernacularTitle:雌激素对骨质疏松大鼠牙槽骨改建过程中IL-1表达的影响
- Author:
Xiaohong LI
;
Hongling SI
;
Xiaochen LIU
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Estrogen;
IL-1;
Alveolar bone
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of estrogen on the expression and distribution of IL-1 in the remodeling osteoporotic alveolar bone.Methods:Ovariectomy was performed on 30 female SD rats and sham operation on 15(control group).When osteoporosis was developed in the 30 ovary-removed rats,the left maxillary molars of all the rats were extracted.On the following day 15 of them were treated with intramuscular estrogen injection at 20 ?g/kg once every 3 days(treatment group).Another 15 rats with ovary removed received no treatment(osteoporosis group).7,30 and 60 days after teeth extraction 5 rats were killed respectively in each group.IL-1 expression in alveolar bone was examined immunohistochemically,and semiquantitative analysis of cellular-staining intensity was done by microphotometry.Results:The positive IL-1 expression were mainly located in the osteoclasts,vascular endothelial cells and fibroblasts.7 days after teeth extraction the cellular-staining intensity of IL-1 in control group,osteoporosis group and treatment group was 0.11?0.019,0.36?0.038 and 0.18?0.025 respectively(control or treatment group vs osteoporosis group,P
