Repair of bone defects with osteoid hydroxyapatite in rabbits
- VernacularTitle:类骨质羟基磷灰石修复骨缺损的实验研究
- Author:
Shimei WANG
;
Suqin XIAN
;
Yunmao LIAO
- Publication Type:Journal Article
- Keywords:
Biocompatibility;
Bone defects reconstruction;
Hydroxyapatite;
Tricalcium phosphate
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of osteoid hydroxyapatite(OHA)in repair of bone defect.Methods:Bone defect in the size of 9 mm?5 mm?4 mm was made in bilateral thigh-bone entocondyle in 12 rabbits,OHA was implanted in the defects on one side and hydroxyapatite(HA)on another side.2,4,8 and 12 weeks after operation 4 rabbits were killed respectively,bone samples with the implants were prepared and examined by roentgenography,histology and SEM.New bone formation was determined by measuring the area of new bone in the samples.Results:Gross imspection and roentgenography observation showed that the defects were repaired in both groups 12 weeks after operation.Histological examination showed that new bone was increasing,absorption and disintegration of the implants were progressing from 2 to 12 weeks after operation.4,8 and 12 weeks after operation larger new bone area was found in OHA implanted defects than that in HA implanted(P
