Relationship between Slit expression and angiogenesis in carcinogenesis of human oral mucosa
- VernacularTitle:口腔黏膜癌变过程中Slit蛋白的表达及其与血管生成的关系
- Author:
Bing HAN
;
Lijing WANG
;
Yuguang MA
;
Yuan ZHAO
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
Slit;
Dysplasia;
Squamous cell carcinomas;
Angiogenesis;
Immunohistochemistry
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
bjective: To study the expression of Slit protein and vascular endothelial cell growth factor(VEGF) in carcinogenesis of human oral mucosa and to investigate the relationship between the Slit and angiogenesis.Methods: The expression of Slit protein and VEGF was detected using immunohistochemical method,microvessel density (MVD) was counted following immunostaining with anti-vWF antibody in 40 cases of human oral squamous cell carcinoma(OSCC),18 cases of simple hyperplasia,20 cases of dysplasia,20 cases of carcinoma in situ and 19 cases of normal oral mucosa(NOM).Results The positive expression of Slit was detected in 34 cases of OSCC,4 of simple hyperplasia,7 of dysplasia,9 of carcinoma in situ and 1 of NOM(P
