The effect of overdose fluoride on the expression of bFGF in rat dental pulps
- VernacularTitle:bFGF在氟中毒大鼠切牙牙髓中的表达和意义
- Author:
Yu WU
;
Kexin HE
;
Yiping YANG
- Publication Type:Journal Article
- Keywords:
Fluoride;
Dental pulp;
Rat;
Fibroblast growth factor
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of overdose fluoride on the expression of bFGF in rat's dental pulps.Methods:NaF at 20 mg/(kg?d) was given to each of 10 Wister rats by stomach perfusion for 8 weeks, another 10 rats were given the same volume of distilled water as the controls.After treatment,HE staining was used to observe the morphology of the teeth, immunohistochemical staining was adopted for study the expression of bFGF in the dental pulps of the rats.Results:The enamel layer and dentin layer of the incisors in NaF treated rats were thinner than those in the controls,the interglobular dentin was increased and the expression of bFGF in dental pulp and inner dentin was inhibited in the NaF treated rats(P
