The relation among P27~(Kip1) expression,cell cycle distribution and apoptosis in oral cancer following induction chemotherapy
- VernacularTitle:口腔癌诱导化疗中P27~(Kip1)表达与细胞周期、凋亡关系的研究
- Author:
Wei TANG
;
Weidong TIAN
;
Youchao TANG
- Publication Type:Journal Article
- Keywords:
Mouth;
Squamous cell neoplasms;
Induction chemotherapy;
p27~(KiP1);
Apoptosis
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the significancy of P27 Kip1 expression, cell apoptosis and cell cycle distribution in the evaluation of sensitivity in oral cancer chemotherapy. Methods:40 cases of oral tumor were treated with MTX,CDDP and PYM by subcutaneous implantable drug pump.Operation was performed 2~4 weeks after the induction chemotherapy. Cell cycle distribution, apoptosis and P27 Kip1 protein expression in the removed tumor tissue were detected by fllowcytometry and indirect fluoressent assay pre-and post-treatment.Results:(1)After induction chemotherapy S,G_2M and PI ration in cell cycle distribution decreased,G_0/G_1, AP and FI_ p27 increased(P
