Micronucleus calculation in exfoliated cells of oral mucosa before and after radiotherapy in the patients with head and neck tumor
- VernacularTitle:头颈部放疗患者的口腔黏膜脱落细胞微核计数的初步研究
- Author:
Ping ZHANG
;
Hongwei LIU
- Publication Type:Journal Article
- Keywords:
Radiotherapy;
Exfoliated cells;
Micronuclei
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the number of micronucleus in exfoliated cells of oral mucosa before and after radiotherapy in the patients with head and neck tumor. Methods:30 patients with head and neck tumor 1-22 years after radiation, 30 patients with head and neck tumor at completion of radiation of 40-86 Gy and 30 healthy controls were included. The micronucleus in exfoliated cells of oral mucosa were investigated by smear examination and Feulgen and fastgreen staining.Results:The micronuleus (% of cells with micronuleus) in the exfoliated cells of oral mucosa in the healthy controls was 0.18?0.14, in the patients before radiotherapy 0.18?0.12, in the patients at completion of radiotherapy 0.73?0.35, in the patients 1-22 years after radiotherapy 0.20?0.17.Conclusions:Radiotherapy may increase the number of micronucleus and the increace is reversible after radiotherapy.
