The relationship between telomerase activity and the expression of proliferating cell nuclear antigen in oral squamous cell carcinoma
- VernacularTitle:口腔黏膜鳞状细胞癌端粒酶活性与PCNA表达的关系
- Author:
Guirong ZHANG
;
Qing ZHOU
;
Ming ZHONG
;
Jie WANG
;
Ruiwu LI
- Publication Type:Journal Article
- Keywords:
Oral mucosa;
Carcinoma;
Squamous cell;
Telomerase;
Proliferating cell nuclear antigen
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between telomerase activity and the expression of proliferating cell nuclear antigen(PCNA) in oral squamous cell carcinoma (OSCC). Methods:Telomerase activity and expression of PCNA in 68 cases of OSCC,34 cases of epithelium immediately adjacent to carcinomas and 12 cases of normal oral mucosa were detected by TRAP-PCR-ELISA and immunohistochemical SP method. Results:The positive rate of telomerase in OSCC, the epithelium immediately adjacent to carcinomas and the normal oral mucosa was 67.65%(46/68), 8.82%(3/34) and 0(0/12) respectively. Telomerase activity in OSCC was related to the grade of the clinicopathology(P
