Expression of vascular endothelial growth factor and nitric oxide synthase in oral squamous cell carcinoma
- VernacularTitle:口腔鳞癌中NOS和VEGF的表达与血管生成及临床病理因素的关系
- Author:
Xiaoguang LI
;
Yanxiu WANG
;
Xianyong YANG
;
Qing WANG
;
Yi LI
- Publication Type:Journal Article
- Keywords:
Mouth;
Squamous cell carcinoma;
Vascular endothelial growth factor;
Nitric oxide synthase;
Angiogenesis
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relation among inducible nitric oxide synthase(iNOS), endothelial nitric oxide synthase(eNOS) and vascular endothelial growth factor (VEGF)in oral squamous cell carcinoma(OSCC) and their relation to clinical pathology and angiogenesis.Methods:OSCC tissue specimens were surgically obtained from 64 patients,the expression of iNOS,eNOS and VEGF in the samples were studied by immunohistochemistry technique. Microvessel density(MVD) was measured by counting the endothelial cells stained with anti-FⅧRAg antibody. Results: ①Positive VEGF and iNOS and eNOS immunostaining was detected in 39(60.94%),42(65.63%)and 45( 70.31%)of the cases respectively.②Expression of VEGF was significantly related to that of iNOS(P05).③MVD in OSCC tissue was positively correlated with the expression of VEGF and iNOS(P05).④VEGF expression was positively correlated to the pathological grade of OSCC(P0.05).Conclusion:iNOS,rather than eNOS, plays a positive role in OSCC development.iNOS and VEGF have a positive correlation in angiogenesis of OSCC.
