Relationship between the infection of human herpesvirus 6 and oral squamors cell carcinoma
- VernacularTitle:人疱疹病毒6型感染与口腔鳞癌相关性的研究
- Author:
Junlian LIU
;
Zhikai XU
;
Yan JIN
;
Yu ZHAO
;
Bin LU
;
Kun YAO
;
Zhongying NIU
- Publication Type:Journal Article
- Keywords:
Human herpesvirus 6;
Mouth;
Squamors cell carcino ma;
Pathogenesis
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship between human herpes vi rus 6 (HHV-6) infection and oral squamors cell carcinoma. Methods: The serum anti-HHV-6 antibody titers from 16 cases of oral squamors cell carcinoma (OSCC) and 16 control subjects were detected by indirect immunofluores cence assay. HHV-6 DNA in peripheral blood mononuclear cells was amplified by P CR and the specificity was confirmed by Southern-blot hybridization with an int ernal probe oligonuclotide. An immunohistochemical staining was used to detect H HV-6 antigen in OSCC tissues. Results: Positive expression of s erum HHV-6 IgG antibody was found in all the cases of OSCC and in 12 of the 16 controls. Geometric mean titer of OSCC group and control group was 1∶118 and 1 ∶64 respectively (P
