The expression of MMP-1, COX2 induced by IL-1? in human dental pulp cells
- VernacularTitle:白细胞介素-1?诱导牙髓细胞的金属蛋白酶-1和COX2的表达
- Author:
Qun LU
;
Xuedong ZHOU
;
Jun CAO
- Publication Type:Journal Article
- Keywords:
Dental pulp cells;
Interleukin-1;
Metalloendopeptidases;
Cyclooxygenase-2
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of endogenous IL-1? on the expression of matrix metalloproteinases (MMPs) and COX2 in dental pulp cells. Methods:Human dental pulp cells were treated with human recombinant IL-1? at 1 nmol/L in serum-free medium for 18 h. Then the cells were collected and total RNA was isolated, MMPs and COX2 mRNA expression was assessed by semiquantitative RT-PCR. Results:IL-1? at 1 nmol/L induced the expression of COX2 and MMP-1 mRNA in human dental pulp cells. Conclusion:IL-1? may contribute to stimulating expression of MMPs and COX2 in the dental pulp during pulpitis.
