Effects of transforming growth factor ?1 on gene expression in oral squamous cell carcinoma cell lines
- VernacularTitle:外源性转化生长因子?1对口腔鳞癌细胞中相关基因表达的影响
- Author:
Xiaoming JIN
;
Jinrong LI
;
Yaxin LI
;
Zubing LI
- Publication Type:Journal Article
- Keywords:
Transforming growth factors;
Squamous cell neoplasms;
Gene expression
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the role of transforming growth fa ctor ?1(TGF-?1) in the procession of human oral squamous cell carcinoma. Methods: Immunohistiochemical techinic was used to determine o ncogene c-myc,c-erbB2,TGF-?1 and EGFR protein expression in oral squamou s cell carcinoma cell line TSCCa and metastasis carcinoma cell line GNM treated by different levels of TGF-?1. Results: TGF-?1 showed different effects on the two cell lines. TGF-?1 significantly increased the expression of C-myc,CerbB2 and slightly enhanced TGF-?1 and EGFR protein expression in GNM cells, while TGF-?1 decreased the expression of C-myc,C erbB2,TGF-?1 and EGFR in TSCCa cells; moreover, the changes of protein ex pression of C-myc,CerbB2 were dose-dependent on TGF-?1. Conclusi on: TGF-?1 have different role in the oral squamous cell carcinoma cell lines.
