The expression of Rb and P~(53) in oral leukoplakia and oral squamous cell carcinoma
- VernacularTitle:口腔白斑及鳞癌中Rb、P~(53)蛋白的表达
- Author:
Yi LU
;
Wenxin GAO
;
Zhongying NIU
;
Jie OUYANG
;
Shenggen SHI
;
Ping JIANG
- Publication Type:Journal Article
- Keywords:
Oral leukoplakia;
Squamous cell neoplasms;
Imm unohistochemistry
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the expression of proteins Rb and P 53 in leukoplakia (LK) and squamous cell carcinoma (SCC) of oral muco sa. Methods: The expression of proteins Rb and P 53 was determined by immunohistochemical S-P method. Paraffin sections of 33 s amples of SCC and 20 of LK were immunohistochemically stained and analyzed. Results: (1)The expression of Rb in OLK, OSCC was not si gnificantly different from that in normal oral mucosa ;(2)the overexpression of mutant P 53 were found in OLK and its expression was increasing with dysp hasia degree (P
