Effects of tumor necrosis factor-? and interferon-? on proliferation of oral submucous fibrosis-derived fibroblasts
- VernacularTitle:TNF-?和IFN-?对OSF成纤维细胞的增殖影响
- Author:
Yingfang WU
;
Jieying Peng
;
Changyun FANG
;
Guoying QUE
- Publication Type:Journal Article
- Keywords:
Oral submucous fibrosis;
Fibroblasts;
Proliferati on;
Tumor necrosis factor-?;
Interferon type II
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objection: To investigate the effects of tumor necrosis factor-?(TNF-?)and interferon-?(IFN-?) on the proliferation of fibrobl asts from healthy persons(NM-FB) and patients with oral submucous fibrosis(OSF -FB).Methods: Fibroblast cultures were established from t he buccal mucosa of five healthy individuals and six patients with OSF. The effe cts of TNF-? and IFN-? on the proliferation of NM-FB and OSF-FB were studi ed by MTT colorimetric assay.Results: TNF-? at 100～10 0 00 U/ml stimulated NM-FB and OSF-FB proliferation (P
