Effects of dexamethasone on TGF-?_1 and TGF-?_2 expression during the induction of cleft palate in mice
- VernacularTitle:地塞米松诱发先天性腭裂对TGF-?_1、TGF-?_2表达的影响
- Author:
Mohong DENG
;
Xing LONG
;
Hongli LI
;
HongmeiDONG
- Publication Type:Journal Article
- Keywords:
Dexamethasone;
Cleft palate;
Transforming growth factor - ?
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of TGF-? 1 and TGF-? 2 on cleft palate formation .Methods:30 pregnant NIH mice in experimental group were injected with dexamethasone (50 mg/kg) intr aperitoneally in GD 12 12 ,30 mice in control group were given the same vo lume of NS.Fetuses were removed out in GD13 12 ,GD14 12 and GD15 12 , heads of the mice were sliced in coronal plane.Expression of TGF-? 1 an d TGF-? 2 in embryonic palate were detected by immunohistochemical methods: Results:Dexamethasone (50 mg/kg) induced cleft palate in NI H embryos,and expression of TGF-? 1 and TGF-? 2 in palate tissues was h igher in the experimental group than that in the control (P
