Cerulenin induces apoptosis of the cells in oral squamous cell carcinoma
- VernacularTitle:浅蓝菌素诱导口腔鳞状细胞癌细胞凋亡的实验研究
- Author:
Ye ZHANG
;
Chuanbin GUO
;
Guangyan YU
- Publication Type:Journal Article
- Keywords:
Fatty acid synthesis;
Cerulenin;
Squamous cell carcinoma;
Apoptosis
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Subjective: To observe apoptosis of the cells in oral sq uamous cell carcinoma(SCC) induced by cerulenin. Methods: SCC TCA-83 cells and fresh tissue of SCC of tongue from 5 patients were expos ed to cerulenin (10 mg/ml) for 24 hours, then the genosome DNA of the cells was extracted and electrophoresed; the fresh tissue of SCC was assessed by TUNEL labeling. Results: DNA gel electrophoresis showed typical apoptic DNA ladders from TCA-83 cells. The rate (%) of TUNEL-positive cells in cerulenin treated tissue of SCC was 29.0?2.6～40.6?16.2,that in the control 2 . 0?1.7～14.7?0.6 (P
