The relation among nm23-H_1 gene expression,DNA contents and lymph node metastases of head and neck squamous cell carcinoma
- VernacularTitle:头颈部鳞癌抑癌基因nm23-H_1的表达、DNA倍体与淋巴结转移的关系
- Author:
Gengsheng SHI
;
Meifu GAN
;
Baoguo CHEN
- Publication Type:Journal Article
- Keywords:
Squamous cell neoplasms;
Lymphatic metastasis;
nm23-H 1;
DNA ploid;
S phase
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relation among nm23-H 1 expression,DNA contents and lymph node metastases of head and neck squamous cell carcinoma(HNSCC).Methods:Fresh specimens from 30 previously untreated patients with HNSCC were examined for the determination of nm23-H 1 expression with immunohistochemistry, Aneuploid and S-phase fraction(SPF) with flow cytometry(FCM).The association among these parameters with lymph node metastases was studied.Results: nm23-H 1 expression was found in 18 cases (60%).and aneuploid in 20 (66.7%).Correlation was found between lymph node metastasis and nm23-H 1 protein expression (P
