Inhibitory effects of homoharringtonine and/or methoxsalen on highly metastatic human mucoepidermoid carcinoma Mc3 cells
- VernacularTitle:高三尖杉酯碱、甲氧沙林对粘液表皮样癌Mc3的抑制作用
- Author:
Yan LI
;
Junzheng WU
;
Zhenqiang SITU
;
Bin LIU
;
Xiaohong DUAN
;
Jinwu CHEN
;
Feng LI
;
Jie LI
- Publication Type:Journal Article
- Keywords:
Mucoepidermoid carcinoma;
Neoplasm metastasis;
Homoharringtoiine;
Methoxsalen
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objctive: To study the inhibitory effects of homoharringtonine(HHT) or methoxsalen (8-MOP) or in combinnation on humen highly metastatic mucoepidermoid carcinoma Mc3 cells. Methods: Mc3 cells were exposed to the drugs or their combination at various concentrations. The inhibitory effects were tested with MTT assay. Results: The IC 50 values of HHT and 8-MOP were 79.43 ng/ml and 5 980 ng/ml respectively, HHT at the doses of 1-320 ng/ml combined with 8-MOP at 800, 4 000 and 20 000 ng/ml the CI 50 values were 0.76?0.33 and 0.15 respectively.Conclution: The data indicate that combination of HHT with 8-MOP is synergic in the inhibition of Mc3 cell growth.
