Apoptosis, proliferation and bcl-2 protein expression in human tongue squamous cell carcinoma and human tongue squamous cell papilloma
- VernacularTitle:舌癌、舌乳头状瘤中细胞凋亡和细胞增殖及其与Bc1-2蛋白表达关系
- Author:
Keqian ZHI
;
Zhaoquan LIN
;
Xiangmin YUAN
;
Mingyu WEN
- Publication Type:Journal Article
- Keywords:
Proloferating cell nuclear antigen;
bcl-2;
Apoptosis;
Tongue;
Squamous cell carcinoma;
Immunohistochemistry
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relation between proliferation, apoptosis and Bcl-2 in human tongue squamous cell carcinoma(TSCC). Methods: Apoptosis, prolifexation and Bcl-2 protein expression were examined in 7 cases of normal tongue mucosa, 20(10 of Han and 10 of Uygur people) of tongue squamous cell papilloma (TSCP) and 42 of TSCC (30 of well-differentiated and 12 of middle-differentiated ) with immunohistochemical and in situ cell death detection technique. Results: The apoptosis index (TI) and the proliferation index (PI) showed no significant difference between Han and Uygur people or between male and femae, TI and PI in human TSCP were heigher than those in normal tongue mucosa, The proliferation was enhanced and apoptosis was inhibited according to dysplasia degree(P
