Bone formation induced by purified BMP and by recombinant human BMP-2
- VernacularTitle:基因重组人骨形成蛋白-2和牛骨形成蛋白异位诱导成骨的比较
- Author:
Yimin DAI
;
Xinmei CHEN
;
Tianqiu MAO
;
Liang HAN
;
Qin MA
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic protein;
Coral/PLA;
Composite artificial bone;
Osteoconductive
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the biodegradable of coral PLA composite artifical bone combined with bBMP or rhBMP as a new kind of bone substitute material. Methods: The composites were implanted into the muscle pouches of mice after combined with rhBMP-2 or bBMP respectively. Ectopic osteoinductive activity of rhBMP-2 or bBMP was examined and compared by histology and histo-morphometry.Results: rhBMP-2 and bBMP had different osteoinductivety. rhBMP-2 appeared to induce less bone and more angioid tissue and marrow. While bBMP seemed to have opposite effects. Conclusion: bBMP is more osteoinductive than rhBMP-2.
