Repair of bone defect with chitin/rhBMP2/collagen complex
- VernacularTitle:几丁质/rhBMP2/胶原复合物修复骨缺损的实验研究
- Author:
Fulin CHEN
;
Tianqiu MAO
;
Changyong WANG
;
Ming ZHAO
;
Huixin WANG
- Publication Type:Journal Article
- Keywords:
Chitin;
Bone morphogenetic protein;
Collagen;
Bone substitute material
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the feasibility of chitin as bone substitute material and carrier of rhBMP2.Methods: Porous chitin and chitin/rhBMP2/collagen complex were implanted into calvarial defects in 8 rabbits. Bone repairing ability was assessed by radiographic and histological observation. 2 rabbits without implantation were served as controls. Results: Chitin had certain bone conductive ability. When combined with rhBMP2,a complex possessing both bone conductive activity and bone inductive activity was produced. The complex had greater bone repairing ability than chitin alone. Conclusion: Chitin may be used as a bone substitute material and carrier of BMP. But its mechanical strength and surface activity should be improved.
