The effects of recombinant human insuline-like growth factor-1 and basic fibroblast growth factor on the proliferation of periodontal ligament cells
- VernacularTitle:胰岛素样生长因子和碱性成纤维细胞生长因子对人牙周膜细胞增殖的影响
- Author:
Naimei YUAN
;
Ling WAN
;
Xianhua ZHANG
;
Zhifen WU
- Publication Type:Journal Article
- Keywords:
Periodontal ligament;
Cells, Insulin like growth factor 1;
Basic fibroblast growth factor
- From:
Journal of Practical Stomatology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of human insuline like growth factor 1 (rhIGF 1) and/or basic fibroblast growth factor (bFGF) on the proliferation of periodontal ligament (PDL) cells. Methods: PDL cells were exposed to rhIGF 1 and/or bFGF at various concentrations for 1,3,5 and 7 d respectively. The proliferation of the cells was studied with MTT assay.Results: rhIGF 1 at 3.125～25.000 ?g/L or bFGF at 0.1～10 ?g/L promoted PDL cells growth in a dose and time dependant way.3.125 ?g/L of rhIGF 1 and 1 ?g/L of bFGF showed stronger effects on cell growth than both used individually.Conclusion: rhIGF 1 and/or bFGF can promote the proliferation of PDL cells.
