Association of IL-1B+3953 polymorphism with chronic periodontitis
- VernacularTitle:IL-1B+3953/Taq I基因型多态性与慢性牙周炎相关关系的研究
- Author:
Haiyun HUANG
;
Ruyu PANG
;
Jincai ZHANG
;
Ping HUANG
;
Yunhui ZHANG
- Publication Type:Journal Article
- Keywords:
Interleudin-1;
Periodontititltls;
Susceptibility;
Gene polymorphisms
- From:
Journal of Practical Stomatology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To examine the distribution of IL-1B+3953 genotypes of Han nationality people with different periodontal health status and to evaluate if there is an association between the genotype of IL-1B+ 3953 and the severity of periodontitis. Methods: 271 subjects of Han nationality were selected, among them there were 85 cases with severe chronic perioodontitis(group①), 97 cases with light and mild chronic periodontitis (group ②) and 89 subjects of periodontal healthy control(group ③). Full periodontal examinations were taken including clinical periodontal tissue attachment loss measurements of full-mouth, periodontal pocket depths and bleeding on probing. DNA samples were obtained with buccal swabbing technique and were further analyzed for IL-1B+3953 genotype polymorphisms using PCR-RFLP-based method. Results: In group ① the distribution (%) of Ⅰ / Ⅰ, Ⅱ / Ⅰ and Ⅱ / Ⅱ was 80, 20 and 0; In group ② 85. 57, 14. 43 and 0; in group ③ 95. 51, 4. 49 and 0, respectively(p
