Effects of Nephrectomy and Interferon Administration on Immunological Parameters in Patients with Renal Cell Carcinoma.
- Author:
Joung Byung YOON
1
;
Sang Don LEE
;
Jung Zoo LEE
;
Moon Kee CHUNG
Author Information
1. Department of Urology, College of Medicine, Pusan National University, Pusan, Korea.
- Publication Type:Original Article
- Keywords:
Two-color flow cytometry;
T cell subsets;
Renal cell carcinoma;
Interferon
- MeSH:
Carcinoma, Renal Cell*;
Flow Cytometry;
Humans;
Immunity, Cellular;
Immunotherapy;
Interferons*;
Lung;
Neoplasm Metastasis;
Nephrectomy*;
T-Lymphocyte Subsets;
T-Lymphocytes;
T-Lymphocytes, Helper-Inducer
- From:Korean Journal of Urology
1994;35(12):1303-1308
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To study the changes in the subsets of peripheral blood T-lymphocytes before and after nephrectomy(Nx) and interferon (IFN) therapy, twenty-four patients with renal cell carcinoma (RCC), who were received radical Nx in all, were divided into three groups; one group consisted of 5 patients with lung metastasis who had been administrated IFN-alpha(M1 group), another group consisted of 10 patients without metastasis who had been administrated IFN-alpha(MO group), and the other group consisted of 9 patients without metastasis who had not been administrated IFN-alpha(IFN(-) group). Immunological parameters such as the percentage of CD3, CD4,CD8 positive cells and the ratio of percentage of CD4/CD8 positive cells were examined by two color flow cytometry. The value of CD4 positive cells showed a significant increase after Nx and the administration of IFN-alpha(P<0.05). The value of CD3 and CD8 positive cells showed no particular changes in all groups. The ratio of percentage of CD4/CD8 positive cells showed a tendency to increased after Nx and administration of IFN-alpha. There was a correlation between the administration of IFN-a and the changes of percentage of CD4 positive cells. We suggest that the administration of IFN-a lead to the increase of helper T cells and immunotherapy such as IFN in RCC patients has some benefits on cellular immunity.
