The effect of glial cell line derived neurotrophic factor on facial nerve regeneration following injury
- VernacularTitle:胶质细胞源性的神经营养因子促进面神经损伤后再生的实验研究
- Author:
Chen WANG
;
Shuxia ZHOU
;
Yuan LI
- Publication Type:Journal Article
- Keywords:
Neurotrophic factor;
Facial nerve;
Regeneration
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
?Objective: To study the effect of glial cell line derived neurotrophic factor (GDNF) on facial nerve regeneration after injury.Methods:Defect of 5 mm was made in each facial nerve on both sides in 32 rabbits.Silicon tubes were used to bridge the defects.Pure GDNF (15 ?g in 30 ?l silane) was injected into silicon tube on one side and saline (30 ?l) on the other side as the control.Nerve regeneration was studied by morphological observation with HE and Bielschowsky stainning,counting of nerve neurons and axon and measuring of motor nerve conduction velocity.The rest 3 rabbits was as blank contol. Results:7 d and 17 d after operation ,the neuron number in GDNF treated and control groups were 39.2?2.3 and 28.4?1.9,and 33.6?2.1 and 27.1?1.4,respectively ( P
