Prognostic Significance of Deoxyribonucleic acid in Stage T1 Bladder Carcinoma.
- Author:
Jae Mann SONG
1
;
Jeong Hoon JANG
Author Information
1. Department of Urology, Wonju College of Medicine, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
T1 bladder carcinoma;
DNA content;
Flow cytometry
- MeSH:
Aneuploidy;
Bacillus;
Diploidy;
DNA*;
Flow Cytometry;
Follow-Up Studies;
Hand;
Humans;
Neoplasm Grading;
Ploidies;
Recurrence;
Tetraploidy;
Urinary Bladder*
- From:Korean Journal of Urology
1994;35(12):1321-1326
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Flow cytometric nuclear deoxyribonucleic acid (DNA) ploidy analysis was done successfully on 35 specimens of stage T1 bladder carcinoma treated with Bacillus Calmette-Guerin(BCG) between June 1986 and June 1993. The histologic tumor grading was done by the same pathologist. Of the specimens 16(46%) were DNA diploidy, 14(40%) were aneuploidy and 5(14%) were tetraploidy. In the relationship between tumor grade and ploidy, diploidy was seen in all (100%) of 5 patients with grade 1, in 13(48%) of 27 patients with grade 2. On the other hand, non-diploidy in 14(52%) of 27 patients with grade 2, and in all(100%) of 5 patients with grade 3. Mean followup period was 29 months(12-97 months). None of the patients died of tumor during the followup period. None(0%) of 16 patients with diploidy had tumor recurrence, in contrast 8(42%) of 19 patients with non-diploidy tumors recurred(p<0.05). None of the 16 patients with diploidy had progression. but 5(36%) in 14 patients with aneuploidy (5 patients(26%) in 19 patients with non-diploidy) progressed to an advanced stage(p<0.05). The DNA ploidy analysis appears to significantly contribute in the elucidation of possible future recurrence and progression in patients with stage T1 bladder carcinoma.
