Roles of neurovascular unit in cognitive impairment induced by chronic cerebral hypoperfusion
10.3760/cma.j.issn.1671-7368.2017.03.018
- VernacularTitle:神经血管单元在慢性脑低灌注致认知功能障碍中的作用
- Author:
Dapeng WANG
;
Yifang WU
;
Jian HAI
- Keywords:
Brain ischemia;
Cognitive disorders;
Neurovascular unit
- From:
Chinese Journal of General Practitioners
2017;16(3):244-246
- CountryChina
- Language:Chinese
-
Abstract:
Chronic cerebral hypoperfusion (CCH) may result in neurovascular unit (NVU) injury,causing cognitive impairment.The NVU consists of neurons,glial cells,vascular cells and extracellular matrix.The damage of NVU can induce the blood-brain barrier dysfunction,abnormal cell signaling,as well as cognitive impairment.However,its molecular mechanism is unclear.Thus,investigating the role of NUV in CCH-induced cognitive impairment may provide a theoretical basis for the novel treatment of cognitive impairment.
