Changes of Nitric Oxide Metabolite and Tumor Necrosis Factor-alpha in the Urine of Patients with Superficial Bladder Tumors after BCG Immunotherapy.
- Author:
Kwang Sung PARK
1
;
Mee Young CHANG
;
Jung Kap CHOI
;
Jong Suk OH
;
Hyun Chul LEE
;
Byung Kap MIN
Author Information
1. Department of Urology, College of Medicine, Chonnam University, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Superficial bladder tumor;
BCG;
Nitric oxide;
TNF-alpha
- MeSH:
Animals;
Bacillus;
Humans;
Immunotherapy*;
Mycobacterium bovis*;
Necrosis;
Nitric Oxide*;
Tumor Necrosis Factor-alpha*;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urology
1994;35(12):1327-1332
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bacillus Calmette-Guerin(BCG) is widely used in the therapy of superficial bladder tumors. Clinical and animal studies suggest that immunological responsiveness to BCG antigens correlates with anti-tumor activity. But its mode of action is unclear. In this studies, we evaluated the changes of nitric oxide(NO) metabolite and tumor necrosis factor-alpha(TNF-alpha) in the urine of patients with superficial bladder tumors after BCG immunotherapy. Both NO and TNF-alpha in the urine specimens of patients treated with BCG were analyzed prior to BCG instillation and 4, 8 and 24 hours afterwards. After 6th BCG instillation. urinary NO increased significantly and showed a maximum of secretion at eight hours(p<0.05). After 6th BCG instillation, urinary TNF-alpha increased and showed a maximum of secretion at eight hours but had no statistical significance. These results suggest that intravesical BCG therapy increased the urinary NO and TNF-alpha secretion which may be related to the anti-tumor activity.
