Long-term adherence to chemoprevention agents among women at high risk of breast cancer
10.3760/cma.j.issn.1671-7368.2017.04.010
- VernacularTitle:乳腺癌高危者183例化学预防药物应用及长期依从性调查
- Author:
Ning MA
;
Chongzhu HU
;
Enqing WANG
;
Ruixue YUE
;
Huan LI
;
Hui ZHANG
;
Wenjuan ZHANG
;
Zhiying BIAN
- Keywords:
Breast neoplasms;
Carcinoma;
Chemoprevention;
Medication adherence
- From:
Chinese Journal of General Practitioners
2017;16(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
One hundred and eighty three women with high risk of breast cancer identified in Baoding First Central Hospital from June 2007 to June 2014,were enrolled in the study.In these 183 cases,41 received preventive therapy (22.4％),142 did not.Factors associated with acceptance of chemoprevention included older age,menopause,comorbidities,lower level education,being married,higher BMI,having high level hyperplasia of ductal epthelia and counseling to breast specialists (P ＜ O.05);whilenot informed by doctors was the main reason for failed taking preventive agents(95.1％,135/142).Thirteen of 41 women receiving chemoprevention discontinued the therapy (31.7％);no-insurance,no side-effects and higher BMI were related to the discontinuing (P ＜ 0.05).The 1-,2-,3-,and 5-year adherence rates of chemoprevention was 86.1％ (31/36),65.4％ (17/26),59.1％ (13/22),8/13 and 5/10,respectively.The results show that chemoprevention rate is low among Chinese women at high risk of breast cancer,and the long-term adherence to preventive therapy is poor.Corresponding measures should be taken to strengthen the chemoprevention of breast cancer.
