Preparation and Quality Evaluation of Negatively Charged Self-Microemulsifying Drug Delivery System of Curcumin
10.11842/wst.2016.12.022
- VernacularTitle:姜黄素炎症靶向自微乳的制备及质量评价
- Author:
Lehuan LIU
;
Yuwei MAO
;
Yijun LI
;
Jundong DAI
;
Ruixue HUANG
;
Jiaqi YU
;
Jianhong WANG
- Keywords:
Curcumin;
negatively charged;
inflammatory target binding;
self-microemulsifying drug delivery system;
quality evaluation
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2016;18(12):2154-2158
- CountryChina
- Language:Chinese
-
Abstract:
The aim of the study was to prepare and evaluate the quality of negatively charged selfmicroemulsifying drug delivery system of curcumin (NC-CUR-SMEDDS).Based on the CUR-SMEDDS,the optimum amount of excipients was confirmed by the single-factor design experiment taking mean particle size,Zeta potential,drug entrapment efficiency and the drug loadings of curcumin as the evaluation indices for the preparation of NC-CUR-SMEDDS.The quality of NC-CUR-SMEDDS was evaluated by observing its appearance status,transmission electron microscope micrographs and determining particle diameter,Zeta electric potential,drug entrapment efficiency and drug loading.As a result,it was found that the Zeta potential reached -43.43 ± 0.29 mV when 4％ docusate sodium was added.The appearance of NC-CUR-SMEDDS remained clarified and transparent,and the microemulsion droplets appeared spherical without aggregation with uniform particle size distribution.The mean particle size was 14.08 ± 0.082 nm,the drug loading of curcumin was 26.48 mg·g-t and the drug entrapment efficiency was 94.12％.It was concluded that NC-CUR-SMEDDS with high entrapment efficiency and uniform particle size distribution met the requirement of inflammatory target binding in the colon.
