A Pharmacodynamical Study on the Improvement of Senile Drosophilas with Fragmented Sleep with the Administration of Shuang Xia Decoction
10.11842/wst.2016.11.025
- VernacularTitle:双夏汤改善老年果蝇片段式睡眠的药效学研究
- Author:
Yuan XI
;
Qi ZHANG
;
Yan TIAN
;
Zhiqian ZHANG
;
Di GENG
;
Hongying LIN
- Keywords:
Shuang Xia decoction;
senile drosophila melanogaster;
fragmented sleep;
autonomic activity monitoring
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2016;18(11):1993-2000
- CountryChina
- Language:Chinese
-
Abstract:
This study aimed at unfolding the therapeutic effects of freeze-dried powder separated from Shuang Xia decoction (SXD) on female senile drosophila melanogaster with fragmented sleep.Taking drosophilas as the model organisms,the locomotor activity was monitored using the autonomic monitoring software to explore the regulation of fragmented sleep in senile drosophilas by the treatment of SXD.As a result,it was found that the optimum concentration of SXD was 2.50％,while the desirable therapeutic duration was 4 days.In comparison with the control group,35-day-old virgin drosophilas'sleep was prolonged in the SXD group and the positive control group.The positive drug mainly affected their sleep in the daytime,while SXD impacted their sleep at night featuring the prolonged fragmented sleep.In conclusion,it was demonstrated that the freeze-dried powder of SXD effectively alleviated intermittent insomnia in the female senile drosophilas.Compared with positive drug,SXD also mitigated intermittent insomnia at night without significant changes in the sleep of the drosophilas in the daytime.Above all,SXD was beneficial in the regulation of sleep-wake rhythm in the drosophilas.
