Advances in Biosynthesis and Metabolic Engineering of Tropane Alkaloids
10.11842/wst.2016.11.011
- VernacularTitle:托品烷生物碱生物合成与代谢工程研究进展
- Author:
Wei QIANG
;
Yufang FAN
;
Zhihua LIAO
- Keywords:
Tropane alkaloids;
biosynthesis;
metabolic engineering
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2016;18(11):1899-1907
- CountryChina
- Language:Chinese
-
Abstract:
Tropane alkaloids,such as hyoscyamine (or its more stable racemate atropine) and scopolamine,are remembered as the oldest drugs in medicine with wide pharmaceutical applications clinically for their mydriatic,antispasmodic,anticholinergic,analgesic and sedative properties.Presently,the supply of tropane alkaloids are entirely rested on their isolation from plant materials,yet the low contents of tropane alkaloids in plants raise the requirement to breed new varieties of high-yield tropane alkaloids and improving the production of tropane alkaloids in hairy root cultures or plants by biotechnology has be a research focus in the field of secondary metabolism.For the past decade,there have been important progresses on biosynthesis of tropane alkaloids and their molecular biology,some new pathway genes have been identified and many achievements have also been acquired in metabolic engineering of tropane alkaloids.This review summarized the recent advances in above aspects,and the problems and orientations of future research are also discussed and proposed.
