Neuroremodeling and depression
10.3760/cma.j.issn.1674-6554.2016.12.018
- VernacularTitle:神经重构与抑郁症
- Author:
Hongbing LI
;
Zihu TAN
- Keywords:
Depression;
Neuroremodeling;
Neuroendocrine;
Genomics
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2016;25(12):1142-1146
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common mental and psychiatry disorder. Depression is easy to recur and hard to cure.These urgent problems origin from the limited understanding of this disease and the big heteroge-neity in its genology. Generalized from recent relative papers we discovered that the important onset and sus-taining basis of depression is neuroremodeling,which includes the persistent changes of histocytology,ultra-structure of synapse and abnormal expressions of gene and protein of neurons in key brain regions,and so on. These changes affect the correct dealing on the neural message which lead to depression and become the sus-taining biological basis. Therefore the key strategies to prevent and cure depression lie on preventing,individ-ual therapy and reversing neuroremodeling.
