Progress of autophagy in acute promyelocytic leukemia

VernacularTitle:自噬在急性早幼粒细胞白血病中的研究进展
Author: Yun ZHUANG ; Ou JI ; Qun SHEN
Keywords: Leukemia,promyelocytic,acute; Autophagy; Apoptosis
From: Journal of Leukemia & Lymphoma 2016;25(12):760-764
CountryChina
Language:Chinese
Abstract: Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia, characterized by the reciprocal chromosomal translocation of t (15;17)(q22;q21), which generates PML-RARαfusion protein. All-trans-retinoic acid (ATRA) and As2O3 could induce APL cells to differentiation and apoptosis, respectively, making APL become the first curable leukemia. Autophagy is one of metabolic mechanisms to maintain cell homeostasis. Recent studies have showed that autophagy plays an important role in the differentiation of APL cells induced by ATRA/As2O3. Meanwhile, autophagy may affect the sensitivity of APL cells to the pro-apoptotic effect of drugs. Therefore, targeting and regulating autophagy might be a new therapeutic approach of APL and even other leukemia in the future. This article will briefly review the advance of autophagy in APL in recent years.