Serum S-100 protein levels in children with Henoch-Schonlein syndrome and its clinical significance
10.3760/cma.j.issn.1671-7368.2017.02.011
- VernacularTitle:儿童过敏性紫癜血清S-100蛋白水平测定及分析
- Author:
Yuan LEI
;
Yue HUANG
;
Jianjun WANG
;
Zengrong LIU
;
Jie YANG
;
Xiaojiang LYU
- Keywords:
Schonlein-Henoch;
S100 Protein;
Child
- From:
Chinese Journal of General Practitioners
2017;16(2):137-139
- CountryChina
- Language:Chinese
-
Abstract:
Seventy eight children with Henoch-Schonlein syndrome (HSP) admitted in our hospital from October 2013 to April 2015 were enrolled in this study,and 30 healthy children were also enrolled as controls.The serum S-100 protein levels were measured with enzyme-linked immunosorbent assay (ELISA)in two groups;and electroencephalogram (EEG) examination was performed in HSP patients.The serum S-100 protein level of HSP group (0.206 ± 0.101) μg/L was significantly higher than that in the normal control group [(0.060 ±0.042) μg/L,P ＜ 0.001];and the serum S-100 protein levels in patients with kidney type (0.284 ±0.099) μg/L and mixed type [(0.284 ±0.043) μg/L,P ＜0.01] were higher than those in patients with skin type (0.151 ±0.098) μg/L,gastrointestinal type (0.138 ±0.036) μg/L and joint type [(0.117 ± 0.065) μg/L,P ＜ 0.001].Abnormal EEG findings were detected in 52 cases (66.7％),however,no clinical manifestations of nervous system were found in those patients.Serum S-100 protein levels were higher in patients with abnormal EEG than those with normal EEG [(0.223 ± 0.099) μg/L vs.(0.173 ± 0.096) μg/L,P ＜ 0.05].The results suggest that the serum S-100 protein is associated with HSP disease severity,and children with HSP may have subclinical neurological damage.
