Serum levels of fatty cytokines in hepatitis B patients with liver fibrosis
10.3760/cma.j.issn.1671-7368.2017.02.006
- VernacularTitle:肝纤维化乙型肝炎患者血清脂肪细胞因子水平特点的研究
- Author:
Wenli XU
;
Wenbin YUAN
;
Jian DING
;
Wenjun JIN
- Keywords:
Liver cirrho;
Hepatitis B;
Cytokine,adipocytes
- From:
Chinese Journal of General Practitioners
2017;16(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the serum levels of fatty cytokines in hepatitis B patients with liver fibrosis.Methods Fifty six hepatitis B patients with liver fibrosis admitted in Wenzhou Central Hospital from April 2014 to March 2016 were recruited as case group and 65 healthy subjects as control group.Serum cytokines including omentin,leptin,adiponectin and visfatin were detected in both two groups and glutamyl endopeptidase (ALT),aspartate aminotransferase (AST) and hepatitis B virus DNA were detected in the case group.Liver biopsy was performed in the case group and histologic activity (HA) and histologic fibrosis (HF) stage were evaluated.Results The level of omentin in the case group was significantly higher than that in the control group [(358-119) vs.(305 ± 108) μg/L,t =2.236,P =0.037].Serum omentin,visceral fat hormone,leptin and adiponectin were not associated with liver function and HBV-DNA (P ＞0.05).There was no significant difference in adipocytokines levels between the low and high HA group (P ＞ 0.05).The level of omentin in high HF stage group was significantly higher than that in low HF stage group [(398 ± 130) vs.(292 ± 120) μg/L,t =2.648,P =0.009],while the other fatty cytokines did not show significantly differences between high and low HF groups (P ＞ 0.05).Conclusion Serum omentin level is elevated in hepatitis B patients with liver fibrosis and is associated with liver fibrosis severity.
