Effects of neuroticism on memory in patients with first-episode depression and the mediating role of depression

VernacularTitle:首发抑郁症患者神经质人格对记忆的影响及抑郁的中介作用
Author: Ning SUN ; Xiaoting HE ; Qiaorong DU ; Xinrong LI ; Suping LI ; Kerang ZHANG
Keywords: Depression; Neuroticism; Memory
From: Chinese Journal of Behavioral Medicine and Brain Science 2016;25(11):977-980
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between neuroticism and memory in patients with first-episode depression and the mediating effect of depression in this relationship.Methods Hamilton de pression rating scale (HAMD),Eysenck personality questionnaire (EPQ),repeatable battery for the assess ment of neuropsychological status (RBANS) were used to evaluate 278 patients with first-episode depression.Results (1) Neuroticism was negatively correlated with immediate memory(r=-0.26,P＜0.01),delayed memory (r=-0.30,P＜0.01),and positively correlated with depressive symptom (r =0.30,P＜ 0.01).Depres-sive symptom was negatively correlated with immediate memory (r=-0.55,P＜0.01),delayed memory (r=-0.44,P＜0.01).(2) The effect of neuroticism on immediate memory and delayed memory was partially mediated by depressive symptom (β=-0.521,-0.388,P＜0.01).The ratio of mediating effect to total effect in immediate memory was 0.597,and the ratio of mediating effect to total effect in delayed memory was 0.383.Conclusion Memory can be affected by neuroticism through the indirect effect of depression.