Efficacy and adverse reactions of repetitive transcranial magnetic stimulation on general anxiety disorder: a meta-analysis
10.3760/cma.j.issn.1674-6554.2016.07.019
- VernacularTitle:重复经颅磁刺激治疗广泛性焦虑障碍的疗效及不良反应的meta分析
- Author:
Lijun LI
;
Weijiang HU
;
Yakun GAO
;
Qi CHEN
;
Chunxue WANG
;
Ning ZHANG
- Publication Type:Journal Article
- Keywords:
Repetitive transcranial magnetic stimulation;
General anxiety disorder;
Efficacy;
Adverse reactions;
Meta-analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2016;25(7):662-666
- CountryChina
- Language:Chinese
-
Abstract:
Objective Repetitive transcranial magnetic stimulation (rTMS) has gradually been used in the treatment of generalized anxiety disorder (GAD).The efficacy and adverse reactions of repetitive transcranial magnetic stimulation on general anxiety disorder are assessed in the review.Methods Searched databases such as Pubmed,Cochrane library,OVID,CNKI,VIP by computer,and researched published randomized controlled trials (RCTs) focused on repetitive transcranial magnetic stimulation on general anxiety disorder.Meta-analysis was conducted by RevMan 5.3 software.Results A total of 10 RCTs were included,involving 732 general anxiety disorder patients.The were divided into two subgroups,one group is effect observation,the other group is the improvement of curative effect in the treatment process.The effectiveness of intervention of rTMS follow up is better than that of the control group (WMD =-5.02,95％ CI=-6.84--3.20,P＜0.01).The intervention of rTMS group can early ameliorate the symptom of anxiety.The results of low frequency and high frequency rTMS intervention is (WMD =-1.34,95％ CI=-1.97--0.71,P＜0.01;WMD =-2.65,95％ CI=-3.51--1.79,P＜0.01).The adverse reactious of the intervention of rTMS group is less than that of the control group(WMD =-7.04,95％ CI=-11.64--2.43,P＜0.01).Conclusion rTMS intervention in the treatment of GAD patients at the end of the treatment and short-term follow-up efficacy is better,rTMS intervention after the onset of rapid intervention,the intervention group adverse reactions are rare.
