The potential therapeutic effect of BDNF on GABAergic neuroplasticity dysfunction in late-life anxiety
10.3760/cma.j.issn.1674-6554.2016.06.020
- VernacularTitle:老年焦虑症GABA能神经可塑性障碍及BDNF的潜在治疗作用
- Author:
Anhua SHI
;
Xiaofei SUN
;
Ningna ZHOU
- Publication Type:Journal Article
- Keywords:
Late-life anxiety;
Dysfunction of neuroplasticity;
Neurotrophic mechanism;
GABA;
BDNF
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2016;25(6):572-576
- CountryChina
- Language:Chinese
-
Abstract:
Late-life anxiety has a high prevalence and usually co-morbidity with cerebral-and cardiovascular diseases which in turn increases the disability and mortality in old people.The pathology of late-life anxiety is difference from adult with the character of GABAergic neuroplasticity dysfunction.The therapeutic strategy presently can only alleviate the anxious symptom but not ameliorate the neuroplasticity.Brain-derived neurotrophic factor (BDNF) is a critical signaling molecule which regulates the GABAergic neuroplasticity,reduction of BDNF along with aging can induce GABAergic dysfunction which contributes to late-life anxiety.BDNF may exert anxiolytic effects by restoring the GABAergic plasticity and can be a potential therapeutic strategy of late-life anxiety.
