Association of rs1013940 polymorphism in SLC5A7 with Tourette syndrome in Chinese Han popula-tion

VernacularTitle:SLC5A7基因 rs1013940位点多态性与 Tourette 综合征的关联分析
Author: Wenmiao LIU ; Aiqin LI ; Yinglei XU ; Mingji YI ; Shiguo LIU ; Hongzai GUAN
Publication Type:Journal Article
Keywords: SLC5A7; Tourette syndrome; Single nucleotide polymorphism; Transmission dis-equilibrium test
From: Chinese Journal of Behavioral Medicine and Brain Science 2016;25(3):231-234
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between rs1013940 in SLC5A7 and Tourette Syndrome ( TS) in Chinese Han population.Methods Polymorphism was genotyped in 401 TS nuclear fam-ilies trios from china by real-time fluorescent quantitive PCR.Transmission disequilibrium test ( TDT) and Haplotype relative risk ( HRR ) were used to analyze the association between the genetic distrbution of rs1013940 and TS and the results were verified by haplotype-based haplotype relative risk( HHRR) .Results No transmission disequilibrium was found between rs1013940 in SLC5A7 and TS by TDT and HRR( TDT:χ2=0.268, P=0.657, OR=0.728,95%CI=0.366-1.451;HRR:χ2=0.111, P=0.739, OR=0.959,95%CI=0.762-1.466) .HHRR also indicated the same result ( HHRR:χ2=0.276, P=0.599, OR=1.082,95%CI=0.806-1.453) .Conclusion The result reveals that there is no significant association between rs1013940 in SLC5A7 and TS in Chinese Han population.However,the results need to be further validated in different populations.