Association study of clusterin polymorphism rs11136000 with late-onset Alzheimer's disease in Bai population
10.3760/cma.j.issn.1674-6554.2016.03.010
- VernacularTitle:聚集素基因 rs11136000位点多态性与白族人群晚发型阿尔茨海默病的关联研究
- Author:
Hongyu LUO
;
Lixia WANG
;
Yonglei LIU
;
Lin YANG
- Publication Type:Journal Article
- Keywords:
Late-onset Alzheimer's disease;
Clusterin gene;
Polymorphism;
Bai population
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2016;25(3):240-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between clusterin(CLU) gene rs11136000 poly-morphism and late-onset Alzheimer's disease ( LOAD) in Bai population from Dali Bai Autonomous Prefec-ture of Yunnan Province.Methods A case-control study including 109 LOAD patients and 120 normal con-trols matched for age,sex and level of education was taken in Dali Bai population.Polymerase chain reaction (PCR) and single nucleotide polymorphism (SNP) site testing were used to detect genotype and allele fre-quency of CLU SNP rs11136000.SPSS 17.0 was applied to analyze the data.Result ①The different fre-quency ( C:65.60%,T:34.40%,CC:38.53%,CT:54.13%,TT:7.34%) of CLU SNP rs11136000 genotypes and alleles distribution in Bai between LOAD patients and healthy controls showed no statistical significance (χ2=1.529, P=0.216;χ2=2.805, P=0.246) .②The serum total cholesterol ( TC) of LOAD patients was significantly higher than that in that of control group( t=2.508, P=0.013) .Conclusion The results suggest that CLU rs11136000 polymorphism may not be the susceptible gene of LOAD,and high serum total choles-terol is more common in LOAD patients.
