Study on the correlation of visfatin level and atheros clerosis in patients with rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2016.04.009
- VernacularTitle:内脂素水平与类风湿关节炎患者动脉粥样硬化相关性研究
- Author:
Ting ZENG
;
Jingzhong LU
;
Dan SHI
;
Kefeng GU
;
Chaoying SONG
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Atherosclerosis;
Visfatin
- From:
Chinese Journal of Rheumatology
2016;20(4):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the visfatin level changes in patients with rheumatoid arthritis (RA), and to study the correlation of visfatin level and atherosclerosis in RA.Methods Fifty cases of patients were divided to the plaque group (33 cases) and plaque-free group (17 cases) according to the carotid intima media thickness checked by carotid ultrasonography.In addition, their blood lipid level, homeostasis model assessment of insulin resistance (HOMA-IR), rheumatoid factors (RFs), anti-CCP, visfatin etc.were measured.Fifty healthy people were set as the control group.The correlation between the visfatin level of RA patients and atherosclerosis was analyzed.The statistical analysis was carried out with independent t-test,analysis of variance, Spearman correlation analysis and multiple stepwise regression.Results The serum visfatin level of RA plaques group was obviously higher than that of the plaque-free group [(47±22) μg/L vs (34±19) μg/L, t=4.361, P＜0.01].The serum visfatin level of RA patients was positively correlated to HOMA-IR (r=0.567, P=0.001), RF (r=0.502, P=0.003), anti-cyclic peptide containing citrulline, (anti-CCP) (r=0.420, P=0.038) and carotid artery IMT (r=0.596, P=0.001).High-density lipoprotein-C (OR=1.009, P=0.020), HOMA-IR (OR=1.450, P=0.006), anti-CCP (OR=1.005, P=0.014) and visfatin (OR=0.971, P=0.008) were independent relevant factors affecting carotid artery IMT.Conclusion The serum visfatin level of RA patients is closely related to atherosclerosis.
