A preliminary study of resting state regional homogeneity imaging in first-episode adolescent depres-sion
10.3760/cma.j.issn.1674-6554.2016.02.009
- VernacularTitle:青少年首发抑郁症患者静息态脑功能局部一致性研究
- Author:
Peipei LYU
;
Shuying LI
;
Huanhuan LIU
;
Wenbo ZUO
;
Huirong GUO
;
Weili CHANG
;
Yali WANG
;
Zehua LI
- Publication Type:Journal Article
- Keywords:
Depression;
First-episode;
Adolescent;
Resting-state;
Functional magnetic resonance imaging;
Regional homogeneity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2016;(2):139-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the abnormal brain activity of first-episode depression by rest-ing state functional magnetic resonance imaging ( fMRI) .Methods Twenty-one adolescent participants diag-nosed with depression(AD) and 18 healthy controls ( HC) were recruited.Resting state fMRI brain scans were performed on all participants.Regional homogeneity ( ReHo) approach was applied to preprocess the fMRI datasets.The value of ReHo maps were obtained in the whole brain.Results ReHo values in the AD group were higher than those in the healthy controls in the right inferior temporal gyrus ( MINI:66,-24,-20) ,left upper cingulate cortex (-27,47,-6) ,frontal polar (-24,59,14) ,after upper left cingulate cortex (-1,-16,35),after the bottom left cingulate cortex (-2,-38,32),left praecuneus (-1,-48,65) com-pared with that in the healthy controls (P<0.05) .ReHo in the AD group decreased in the right middle tempo-ral gyrus (45,-34,32) compared with that in the healthy controls (P<0.05).Conclusion Extensive ReHo abnormalities were found in the brains of patients with first-episode,drug-naive depression,and these abnor-malities in spontaneous neural activity may contribute to the neuropathology of adolescent depression.
