Association of variants in signal transducer and activator of transcription 4 in Chinese Han population with rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2016.02.003
- VernacularTitle:信号传导和转录活化因子-4的单核苷酸多态性与中国汉族人类风湿关节炎的相关性研究
- Author:
Meng WEI
;
Qingyun XIE
;
Tao WANG
;
Yue CHENG
;
Fan ZHANG
;
Dongyang GUO
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Polymorphism,single nucleotide;
Signal transducer and activator of transcription;
Association
- From:
Chinese Journal of Rheumatology
2016;(2):83-87
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations of variants in signal transducer and activator of transcription 4 (STAT4) in Chinese Han population with rheumatoid arthritis (RA). Methods The study was performed in 228 RA cases and 228 controls. Haplotypes from the HapMap database Chinese population were used to select tag-single-nucleotide polymorphisms (SNPs) (r2=0.9) in STAT4 gene. Twenty-three SNPs located in STAT4 gene were examined by multiplex polymerase chain reaction (PCR) and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS). The Hardy-Weinberg equilibrium (HWE) was tested by a chi-square and Fisherˊs analysis. Differences in genotypes of the STAT4 polymorphism variants were evaluated using a Chi-square test. All statistical analyses were done with Haploview 4.1 software. Results Significant difference was detected in three SNPs (rs11685878, rs129888 and rs16833437) in allele frequencies analysis (χ2=6.014 8, 4.024 8, 5.539 1, P<0.05). Association was detected for three SNPs (rs11685878, rs16833437 and rs12988825) in genotype analysis ( χ2=6.814 9, 6.098 7, 6.691 7, P<0.05). Conclusion STAT4 may associate with susceptibility in Chinese Han population.
