The functional magnetic resonance imaging (fMRI) study of auditory sensory gating in the siblings of schizophrenic

VernacularTitle:精神分裂症患者健康同胞感觉门控的脑功能磁共振成像研究
Author: Bin JI ; Wei MEI ; Yongning ZHUO ; Shuhua MA ; Juzhen JING ; Qiulin WU
Publication Type:Journal Article
Keywords: Schizophrenia; Healthy sibling; Sensory gating fMRI
From: Chinese Journal of Nervous and Mental Diseases 2015;(11):641-645
CountryChina
Language:Chinese
Abstract: Objective To investigate auditory sensory gating potential in the siblings of schizophrenic, to discover the neuroimaging features of sensory gating associated with schizophrenia as intermediate phenotypes. Methods Twelve siblings of schizophrenia patients in the first episodic, and 12 healthy controls matched in gender, age, education under?went MRI scan when performing a auditory sensory gating fMRI task (repeated clicks and single click auditory stimuli). The measure of sensory gating was the contrast of repeated clicks minus single click. The analysis of result was imple?mented in SPM2. Results Compared with healthy controls, schizophrenia patients showed significant overactivation in the right inter cingulate gyrus (x=4,y=8,z=32) and left anterior cingulate gyrus (x=-8,y=4,z=28) during the fMRI senso?ry gating task. Conclusion Sensory gating is overactivated in the cingulate gyrus in siblings of schizophrenic. This pat?tern may be a potential endophenotype of schizophrenia.