Plasma S100B as a predictor for short-term outcome of aneurysmal subarachnoid hemorrhage(aSAH)and in hospital complications

VernacularTitle:血浆S100B蛋白预测动脉瘤性蛛网膜下腔出血短期预后及并发症的研究
Author: Bo YANG ; Yanfang LIU ; Liheng BIAN ; Xingquan ZHAO
Publication Type:Journal Article
Keywords: S100B protein; Aneurysmal subarachnoid hemorrhage; Prognosis; Complication
From: Chinese Journal of Nervous and Mental Diseases 2015;(11):674-678
CountryChina
Language:Chinese
Abstract: Objective To study the ability of S100B to predict the clinical outcomes and complications after aneu?rysmal subarachnoid hemorrhage (aSAH). Method This study is a one-center and consecutive recruitment. Plasma S100B levels were measured by enzyme-linked immune-sorbent assay (ELISA) within 72 hours after onset. The charac?teristics, treatment patterns, complications and outcomes of patients were also analyzed. Results The S100B levels of aSAH patients were higher than that of health controls(28.55 pg/mL vs. 21.20 pg/mL, P<0.001). S100B levels (P=0.05), Hunt-Hess higher scales (P<0.001), delayed cerebral ischemia (P<0.001) and hydrocephalus (P=0.028) were associated with poor outcomes. S100B also can predict complications in hospital. Conclusions The levels of S100B rise during acute phase of aSAH and S100B may be a useful biomarker to predict functional outcomes and complications in hospital.