Effect of childhood abuse on plasma leptin level in adult depression
10.3760/cma.j.issn.1674-6554.2016.03.011
- VernacularTitle:童年受虐对成人抑郁症患者血浆瘦素水平的影响
- Author:
Weihua WANG
;
Yunchuan SUI
;
Li LIU
;
Hanqing ZHAO
;
Guangyao LI
- Publication Type:Journal Article
- Keywords:
Depression;
Childhood abuse;
Leptin
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2016;25(3):244-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of childhood abuse on leptin level in blood plasma of adult depression patients.Methods 106 depression patients were included in this study.Children abuse status,severity of depression anxiety were assessed with the childhood trauma questionnaire (CTQ),Hamil-ton rating scale for depression ( HAMD) and Hamilton rating scale for anxiety ( HAMA) .According to CTQ score subjects were divided into abuse group ( n=38) and non-abuse group ( n=68) .Leptin levels were de-termined using the Enzyme Linked Immunosorbent Assay.Results Of 106 depression patients 35.85%( n=38) had been abused in childhood according to the result of CTQ score.There were significant differences between the abuse group and the non-abuse group in the age of first onset,sex ratio,the total score of the HAMD-24,the total score of HAMA.Leptin level of abuse group ((4.989±2.820)μg/L) was lower than that in non-abuse group((7.324±4.941)μg/L, P<0.05) and control group ((9.811±7.353)μg/L, P<0.01).Leptin level in non-abuse group was lower than that in control group ( P<0.01).Conclusion Childhood abuse obviously influences lep-tin levels of adult depression patients,which may be a risk factor of adult depression development.
