Clinical Efficacy of Triple Therapy Based on Ipratropium Bromide Inhalation in the Treatment of AECO-PD
- VernacularTitle:异丙托溴铵雾化吸入为主三联治疗慢阻肺急性加重期疗效观察
- Author:
Bin QIU
;
Xianming CHEN
- Publication Type:Journal Article
- Keywords:
Ipratropium bromide;
Inhalation;
Chronic obstructive pulmonary diseases;
Acute exacerbation;
Efficacy
- From:
China Pharmacist
2015;18(12):2097-2099
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effects and safety of triple therapy based on ipratropium bromide inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary diseases ( AECOPD) . Methods:Totally 150 patients with acute exac-erbation of AECOPD were randomly divided into control group (75 patients) treated with budesonide combined with salbutamol by in-halation, and treatment group (75 patients) treated with ipratropium bromide inhalation additionally. The clinical effects, dyspnea score, pulmonary function index and blood gas analysis index before and after the treatment and the incidence of adverse reactions of the two groups were compared. Results:The clinical effects of the treatment group was significantly better than that of the control group (P<0. 05). The dyspnea score, pulmonary function index in and blood gas analysis index in the two groups after the treatment were significantly better than those before the treatment(P<0. 05), and the improvement of the treatment group was significantly better than that of control group (P<0. 05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0. 05). Conclusion:Triple therapy including ipratropium bromide inhalation in the treatment of acute exacerbation of AECOPD can ef-fectively alleviate clinical symptoms and signs and improve the lung ventilation function without increased risk of adverse reactions.
