Effect of Single Nucleotide Polymorphisms in ABCC2 on Clinical Drug Application
- VernacularTitle:ABCC2基因单核苷酸多态性对药物临床应用的影响
- Author:
Danyun WEI
;
Hong ZHANG
;
Rui PENG
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
ABCC2;
Single nucleotide polymorphisms;
Transmembrane transport;
Clinical impact
- From:
China Pharmacist
2015;18(12):2152-2156
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the single nucleotide polymorphisms ( SNPs) in ABCC2 and the effect on clinical drug appli-cation. Methods:According to the related articles published in domestic and abroad, the correlation between the single nucleotide pol-ymorphisms in ABCC2 and drug responses was classified and summarized. Results:ABCC2 translocator played an important role in the transmembrane transport of many physiological compounds and exogenous compounds. Numerous studies have demonstrated that the single nucleotide polymorphisms in ABCC2 possibly affected the expression or activity of ABCC2, which leading to the variation in the absorption, distribution and excretion of certain drugs and toxicants. However, the limitation and controversy were still emerged in the results. Conclusion:The influence of ABCC2 single nucleotide polymorphisms on clinical drug application shows significantly referen-tial value for the guidance of medication and the evaluation of efficacy, however, it can not be used as the only indicator yet.
