Single emission computed tomography of cerebral blood flow between unipolar depressed patients and bi-polar depressed patients
10.3969/j.issn.1002-0152.2015.09.001
- VernacularTitle:抑郁障碍与双相障碍脑血流灌注研究
- Author:
Erni JI
;
Haichen YANG
;
Tiebang LIU
;
Nianhong GUAN
;
Jinbei ZHANG
;
yun TANG
- Publication Type:Journal Article
- Keywords:
Major depression;
Bipolar depression;
Regional cerebral blood flow
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(9):513-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristic of regional cerebral blood flow (r-CBF) in patients with major depression disorder (MDD) and bipolar depressed (BPD). Methods The r-CBF imaging was detected by using sin?gle emission computed tomography (SPECT) in 22 treatment naive patients with MDD, 22 treatment naive patients with BPD and 15 healthy controls. The r-CBF was compared between patients and controls. Results Compared to controls, the r-CBF in the bilateral temporal lobe, parietal lobe and basal ganglia significantly decreased in MDD and BPD pa?tients (P<0.001). The r-CBF in the basal ganglia was significantly lower in MDD patients than in BPD patients. Conclu?sion The r-CBF is abnormal in MDD and BPD at the resting state. The r-CBF in the basal ganglia is the main differ?ence between MDD and BPD. The difference might be regarded as a biomarker in distinguishing BPD patients from MDD patients.
